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Longevity science, explained
Evidence-based articles on sleep, nutrition, skin aging, cognitive health, and the science of living longer, better.
Longevity Science
23 articlesLongevity Science
The Hallmarks of Ageing: The 12 Biological Processes Behind Getting Older
Ageing isn't just wear and tear. The 12 hallmarks of ageing, from DNA damage to chronic inflammation, are the scientific map behind today's longevity research, and many respond to everyday habits.
Longevity Science
Epigenetics and Ageing: How Your Genes Are Switched On and Off as You Get Older
The epigenome decides which genes are switched on, and it drifts with age. What twins, famine survivors and ex-smokers reveal, and why a 2023 mouse study suggests epigenetic change may drive ageing.
Longevity Science
Epigenetic Clocks Explained: How DNA Methylation Measures Biological Age
From Horvath's first clock to GrimAge and DunedinPACE: how DNA methylation tests estimate biological age and pace of ageing, how reliable they are, and how to interpret a result.
Longevity Science
Telomeres and Ageing: What Your Chromosome Caps Can and Can't Tell You
Telomeres shorten as cells divide, but longer isn't always better. What the research shows, the cancer trade-off, and why telomere tests are a poor guide.
Longevity Science
Cellular Senescence: How 'Zombie Cells' Drive Ageing and Inflammation
Senescent cells stop dividing but refuse to die, releasing inflammatory signals. Why they protect us early, harm us later, and what mouse studies show.
Longevity Science
Mitochondria and Ageing: Why Your Cells' Power Plants Matter for a Long Life
Mitochondria decline with age, but antioxidant pills don't fix them. Exercise does: interval training boosted mitochondrial capacity by 69% in adults aged 65-80.
Longevity Science
Nutrient-Sensing Pathways: How mTOR, Insulin, AMPK and Sirtuins Link Food to Ageing
Cells constantly sense whether food is plentiful or scarce. How insulin/IGF-1, mTOR, AMPK and sirtuins shape ageing, from twice-as-long-lived worms to rapamycin in mice and Laron syndrome in people.
Longevity Science
Autophagy: The Cell's Recycling System and What It Means for Ageing
Autophagy is how cells recycle damaged parts, and it declines with age. Boosting it extends life in mice, but claims that a specific fast switches it on in people go well beyond the evidence.
Longevity Science
Inflammaging: How Chronic Low-Grade Inflammation Drives Ageing
Chronic low-grade inflammation is linked to diseases behind more than half of all deaths. What drives it, why it may not be inevitable, and the lifestyle steps that lower it.
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