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Nutrition & Metabolism

The Mediterranean Diet:
What It Is, What You Eat and Why It Leads the Evidence

Aevum Protocol10 min read

The Mediterranean diet is based on the traditional eating patterns of countries around the Mediterranean Sea, such as Greece, southern Italy and Spain. It's built on vegetables, fruit, legumes, whole grains, nuts and seeds, with extra virgin olive oil as the main fat, fish and seafood several times a week, moderate amounts of dairy, eggs and poultry, and little red or processed meat or sweets. It has more high-quality evidence behind it than any other named diet. In the Spanish PREDIMED trial of 7,447 adults at high cardiovascular risk, a Mediterranean diet supplemented with olive oil or nuts reduced heart attacks, strokes and cardiovascular deaths by about 30% compared with a low-fat diet. In the CORDIOPREV trial of 1,002 people with heart disease, it cut repeat cardiovascular events by about 25% over seven years. A substudy of PREDIMED found about 52% fewer new cases of type 2 diabetes, without weight loss. In more than 25,000 US women followed for 25 years, those who followed it most closely had a 23% lower risk of death. It's also linked to lower dementia risk. It isn't a strict or restrictive diet but a flexible eating pattern that can be adapted to any cuisine, including Sri Lankan food. This article explains what it is, what you eat, what the evidence shows, its limitations and how to follow it in Sri Lanka.

Key numbers

FindingDetail
PREDIMED (7,447 adults at high risk)About 30% fewer heart attacks, strokes and cardiovascular deaths vs low-fat diet
CORDIOPREV (1,002 people with heart disease, 7 years)About 25% fewer repeat cardiovascular events vs low-fat diet
Lyon Diet Heart Study (heart attack survivors)Cardiac deaths and heart attacks: 14 vs 44 over about 4 years
PREDIMED-Reus (418 adults without diabetes)About 52% fewer new cases of type 2 diabetes, with no weight loss
Women's Health Study (25,000+ women, 25 years)23% lower risk of death with highest adherence
UK Biobank (60,298 adults)Up to 23% lower dementia risk with highest adherence

What it is

The Mediterranean diet was first described by researchers in the 1950s and 1960s, most famously the American physiologist Ancel Keys, who noticed low rates of heart disease in parts of southern Europe despite limited access to medical care. In 2010, UNESCO recognised the Mediterranean diet as part of the cultural heritage of several Mediterranean countries.

It's less a set of rules than a pattern of eating, with a few core principles:

Traditionally it included moderate red wine with meals, but current evidence doesn't support starting to drink for health (see Alcohol and Longevity).

What you eat

Food groupHow oftenExamples
Vegetables and fruitEvery mealLeafy greens, tomatoes, onions, gourds, seasonal fruit
LegumesMost daysLentils, chickpeas, beans, dhal
Whole grainsMost mealsWhole wheat, oats, brown or red rice
Nuts and seedsDaily, a small handfulAlmonds, walnuts, peanuts, cashews, sesame
Olive oil or other unsaturated oilsDaily, main fatExtra virgin olive oil, sesame (gingelly) oil
Fish and seafoodAt least twice a weekSardines, mackerel, tuna, prawns
Yoghurt, cheese, eggs, poultryModerate, a few times a weekCurd, yoghurt, eggs, chicken
Red meatOccasionally, small portionsBeef, mutton, pork
Processed meat, sweets, sugary drinksRarelySausages, cakes, soft drinks
The Mediterranean way of eating: vegetables, fruit, legumes, whole grains, nuts, olive oil and herbs every day; fish at least twice a week; yoghurt, cheese, eggs and poultry in moderation; red meat and sweets occasionally

How it works

The benefits probably come from the whole pattern rather than any single food:

What the evidence shows

Heart disease

PREDIMED was the landmark trial. In Spain, 7,447 adults aged 55-80 at high cardiovascular risk were assigned to a Mediterranean diet with extra virgin olive oil, a Mediterranean diet with nuts, or advice to follow a low-fat diet. The Mediterranean groups had about 30% fewer heart attacks, strokes and cardiovascular deaths. The original 2013 paper was retracted and republished in 2018 after problems were found with randomisation at some sites; a reanalysis that accounted for the 1,588 affected participants found the same results.

CORDIOPREV, published in The Lancet in 2022, assigned 1,002 people with established coronary heart disease, mostly men with an average age of 59.5, to a Mediterranean diet with extra virgin olive oil or a low-fat diet for seven years. There were 87 major cardiovascular events in the Mediterranean group and 111 in the low-fat group, about 25% fewer (hazard ratio 0.745). The trial was supported by olive oil industry foundations.

The earlier Lyon Diet Heart Study in France assigned people who'd survived a first heart attack to a Mediterranean-style diet or a typical "prudent" Western diet. Over an average of 46 months, there were 14 cardiac deaths or non-fatal heart attacks in the Mediterranean group compared with 44 in the control group, equivalent to roughly 50-70% lower risk.

What the Mediterranean diet trials showed: about 30% fewer heart attacks, strokes and cardiovascular deaths, about 25% fewer repeat events in heart disease, and about 52% fewer new cases of type 2 diabetes, each vs a low-fat diet

Type 2 diabetes. In the PREDIMED-Reus substudy, 418 adults without diabetes were followed for a median of four years. New diabetes developed in 10.1% of the olive oil group and 11.0% of the nuts group, compared with 17.9% of the low-fat group: about 52% fewer cases. This happened without calorie restriction or weight loss (see Insulin Resistance).

Longevity. In a 2024 study in JAMA Network Open, researchers followed more than 25,000 healthy women from the US Women's Health Study for over 25 years. Those who followed a Mediterranean diet most closely had a 23% lower risk of death from any cause, 17% lower risk of death from cardiovascular disease and 20% lower risk of death from cancer. Differences in inflammation, insulin resistance and body weight explained much of the benefit (see Eating Patterns for Longevity).

Brain health. In a 2023 study in BMC Medicine of 60,298 UK Biobank participants followed for more than nine years, those with the highest adherence to a Mediterranean-style diet had up to 23% lower risk of dementia, regardless of their genetic risk. The study included only white British and Irish participants, so it may not apply to everyone. The related MIND diet combines Mediterranean and DASH principles specifically for brain health (see The MIND Diet and Brain Health).

Weight. The Mediterranean diet isn't primarily a weight-loss diet, but it's filling, sustainable and doesn't cause weight gain despite being relatively high in fat. Weight loss depends mainly on overall calorie intake.

Evidence strength

Strong.

Moderate.

Limited.

Not supported.

Important limitations.

Risks and who should be careful

The Mediterranean diet is safe for almost everyone, including children, pregnant women and older adults. Points to watch:

A Sri Lankan version

You don't need to eat Greek food to follow the Mediterranean diet. Many Sri Lankan dishes already fit its principles:

See Building a Longevity Plate for a practical rice-and-curry guide.

Mediterranean diet evidence scorecard: strong for fewer heart attacks and strokes and better risk markers; moderate for diabetes and longer life; limited for dementia and some cancers; red wine and refined pasta and pizza not supported

Why this matters for longevity

No other named diet has as much high-quality evidence for preventing heart disease, the leading cause of death worldwide, as the Mediterranean diet. It's also linked to lower risk of diabetes, dementia and early death, and it's flexible, enjoyable and sustainable for life. Its principles, mostly plants, healthy fats, fish and legumes, few processed foods, are shared by almost every eating pattern linked to healthy ageing. For most people, it's the best starting point.

Recommendations by situation

SituationWhat to consider
Healthy adult wanting to eat for longevityA Mediterranean-style pattern adapted to Sri Lankan food is an excellent default
Heart disease or high cardiovascular riskStrongly recommended; strongest trial evidence of any diet
Prediabetes or type 2 diabetesRecommended; watch rice portions and choose whole grains
Wanting to lose weightWorks well with smaller portions; watch oil and nut quantities
Worried about memory or dementiaMediterranean or MIND-style eating
Pregnant or breastfeedingSafe and recommended; avoid alcohol and high-mercury fish
VegetarianEasily adapted with more legumes, nuts, dairy and eggs
On a tight budgetUse local oils, legumes, seasonal vegetables and small fish

Practical notes

Start with a few swaps rather than a complete change: add a vegetable curry or mallung to every meal, have dhal or another legume daily, switch some cooking to olive or gingelly oil, eat fish twice a week, snack on a small handful of nuts, and choose fruit over sweets. Keep red and processed meat occasional. The details matter less than the overall pattern, and the best version is one you enjoy and can keep up for life. Our Longevity Doctors can help you adapt a Mediterranean-style diet to your health, preferences and Sri Lankan food, starting with the free longevity assessment.

References
  1. Estruch R, et al. Primary prevention of cardiovascular disease with a Mediterranean diet supplemented with extra-virgin olive oil or nuts. New England Journal of Medicine, 2018;378(25):e34.
  2. Delgado-Lista J, et al. Long-term secondary prevention of cardiovascular disease with a Mediterranean diet and a low-fat diet (CORDIOPREV): a randomised controlled trial. The Lancet, 2022;399(10338):1876-1885.
  3. de Lorgeril M, et al. Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study. Circulation, 1999;99(6):779-785.
  4. Salas-Salvadó J, et al. Reduction in the incidence of type 2 diabetes with the Mediterranean diet: results of the PREDIMED-Reus nutrition intervention randomized trial. Diabetes Care, 2011;34(1):14-19.
  5. Ahmad S, et al. Mediterranean diet adherence and risk of all-cause mortality in women. JAMA Network Open, 2024;7(5):e2414322.
  6. Shannon OM, et al. Mediterranean diet adherence is associated with lower dementia risk, independent of genetic predisposition: findings from the UK Biobank prospective cohort study. BMC Medicine, 2023;21:81.

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