Cognitive Longevity

Learning New Skills and Brain Health:
What Kind of Mental Challenge Helps

Aevum Protocol8 min read

"Use it or lose it" is one of the most familiar pieces of brain-health advice. The evidence broadly supports it, with some important details. Older people who regularly read, play board games, play music or take part in other mentally engaging activities have lower rates of dementia, and in one large study the most mentally active people developed Alzheimer's about five years later than the least active. Trials show that learning a demanding new skill can change the ageing brain and improve memory. But not every activity helps equally, the gains can fade when you stop, and some skills, such as learning a language for a few weeks, haven't improved general thinking in trials. This guide covers what the evidence supports and how to choose activities that are most likely to help.

Key numbers

FindingDetail
Leisure activities in adults over 75 (469 people, ~5 years)Most mentally active third had 63% lower dementia risk than the least active (HR 0.37)
Each extra point on a cognitive-activity score7% lower dementia risk (HR 0.93)
Cognitive activity and Alzheimer's onset (1,903 people, ~7 years)High activity (90th percentile) diagnosed at 93.6 years vs. 88.6 for low activity (10th percentile): about 5 years later
Synapse Project (learning digital photography and/or quilting, ~15 hours/week, 3 months)Episodic memory improved; social activities alone didn't produce the same gain
Juggling training in older adults (69 people, 3 months)Grey matter increased in visual and memory areas, then reversed 3 months after training stopped
Learning Italian for 11 weeks (160 people aged 65-75)Basic language gained, but no improvement in memory or intelligence vs. relaxation training

Why learning might protect the brain

Two ideas from earlier in this series explain why mental challenge might matter.

Learning a new skill is thought to build both: it challenges the brain in new ways and may strengthen the networks that help it cope with ageing and disease.

What the evidence shows

Observational studies: mentally active people have lower dementia risk. In a landmark study published in 2003, researchers followed 469 people over 75 who didn't have dementia for a median of about five years, during which 124 developed dementia. People who did more cognitively engaging leisure activities, such as reading, board games, playing a musical instrument and dancing, had lower risk. Each additional point on a cognitive-activity score (roughly one activity one day a week) was linked to a 7% lower risk. People in the top third of cognitive activity had a 63% lower risk than those in the bottom third. Interestingly, in this study, most physical leisure activities weren't linked to lower risk, but dancing, which is both physical and mentally demanding, was.

A 2021 study from the Rush Memory and Aging Project followed 1,903 older adults for about seven years. Among the 457 who developed Alzheimer's, people with high cognitive activity (at the 90th percentile) were diagnosed at an average age of 93.6, compared with 88.6 for those with low activity (at the 10th percentile), a delay of about five years. In the 695 people who had brain autopsies, cognitive activity wasn't linked to the amount of Alzheimer's-type damage in the brain. This fits the idea of cognitive reserve: mental activity didn't prevent the disease from developing, but it seemed to help people function for longer despite it.

The limitation of both studies is that they're observational. People who are already developing dementia often become less active years before diagnosis, and mentally active people may differ in other ways. The researchers tried to account for this, but it can't be ruled out entirely.

Stat tiles: 63% lower dementia risk in the most mentally active third of adults over 75 (Verghese et al., NEJM, 2003); about 5 years later Alzheimer's diagnosis in the most mentally active, 93.6 vs. 88.6 years (Wilson et al., Neurology, 2021)

Trials: learning a demanding skill can change the brain and memory.

Timeline diagram: grey matter in visual and memory areas rises from the start to a peak after 3 months of juggling training, then falls back to near the starting level 3 months after stopping, in older adults with an average age of 60 (Boyke et al., Journal of Neuroscience, 2008)

Not every skill helps: the language-learning trial. Learning a language is often recommended for brain health, partly because lifelong bilingualism is linked to later onset of dementia symptoms (see Cognitive Reserve). But in a Swedish trial, 160 healthy adults aged 65-75 were randomly assigned to 11 weeks of learning Italian or to relaxation training. The language learners picked up basic Italian but didn't improve more than the relaxation group on tests of memory, intelligence or working memory. This doesn't mean language learning is useless. It may take much longer, or it may matter more as a lifelong habit than a short course. But it's a reminder that "learn a language" isn't a guaranteed brain boost.

How this differs from brain-training apps. Brain-training games mostly make you better at the games themselves (see Cognitive Training and Brain Games). The skills in the more promising trials, such as photography, quilting, juggling and music, are different. They're complex, real-world activities that use several abilities at once, involve steady progress over weeks or months, and often have a social or creative element.

What seems to matter

Pulling the evidence together, the activities most likely to help share these features:

  1. 1
    Genuinely new

    Doing crosswords you've done for 30 years is less demanding than learning something unfamiliar.

  2. 2
    Challenging

    The Synapse Project found gains only in the high-challenge groups. The task should stretch you, not bore you.

  3. 3
    Sustained

    The trials that showed benefit involved many hours over months. The juggling study suggests gains can fade when you stop.

  4. 4
    Complex

    Activities that combine memory, attention, planning and physical skill (music, dance, crafts, a new sport) exercise more of the brain than a single repetitive task.

  5. 5
    Enjoyable

    You're far more likely to stick with something you like, and sticking with it is what counts.

Recommendations by situation

Working adult in midlife

Approaching or entering retirement

Over 70

Mild cognitive impairment or memory concerns

Limited formal education

Decision guide, learning for your brain: midlife, build one substantial new skill over months; retiring, replace work's mental demands with structured learning; over 70, choose activities that are mental, physical and social; any age, new, challenging and sustained beats easy and familiar

Ideas for Sri Lanka

Practical notes

Mentally active people consistently have lower dementia risk, and trials show that learning a demanding new skill can change the ageing brain and improve memory. But the benefits depend on the activity being new, challenging and sustained, and they can fade when you stop. No single activity has been proven to prevent dementia, and a short language course didn't improve general thinking in one trial. The practical message is to choose something you enjoy that genuinely stretches you, keep at it for months and years, and combine it with the other brain-health foundations in this series, especially exercise, sleep and social connection.

References
  1. Verghese J, et al. Leisure Activities and the Risk of Dementia in the Elderly. New England Journal of Medicine, 2003;348:2508-2516.
  2. Wilson RS, et al. Cognitive Activity and Onset Age of Incident Alzheimer Disease Dementia. Neurology, 2021;97(9):e922-e929.
  3. Park DC, et al. The Impact of Sustained Engagement on Cognitive Function in Older Adults: The Synapse Project. Psychological Science, 2014;25(1):103-112.
  4. Boyke J, et al. Training-Induced Brain Structure Changes in the Elderly. Journal of Neuroscience, 2008;28(28):7031-7035.
  5. Marie D, et al. Music interventions in 132 healthy older adults enhance cerebellar grey matter and auditory working memory, despite general brain atrophy. NeuroImage: Reports, 2023;3(2):100166.
  6. Berggren R, et al. Foreign Language Learning in Older Age Does Not Improve Memory or Intelligence: Evidence From a Randomized Controlled Study. Psychology and Aging, 2020;35(2):212-219.

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